A Facile Method for Conversion of Phenolic Tetrahydroisoquinolines to Benzylamines with Ring Cleavage
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The reaction of N-(cyanomethyl)-6- and -8-hydroxytetrahydroisoquinolinium methiodide with various cyclic amines afforded the corresponding benzylamines via the formation of p- or o-quinone methide in moderate to high yields. pp.2075-2060