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Basic information
Gastric hyperemic response induced by acid back-diffusion in rat stomachs following barrier disruption -- relation to vanilloid type-1 receptors.
Acid back-diffusion and capsaicin increase gastric mucosal blood flow mediated by capsaicin-sensitive sensory neurons (CSN), yet their modes differ in terms of capsazepine-sensitivity. Although the luminal H+ plays a role for the physiological response mediated by CSN, it is unlikely that the results from the interaction of H+ with the capsazepine-sensitive site of TRPV1. |