Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats.

Ohashi N, Tashima K, Namiki T, Horie S.

AITC-induced augmentation of GMBF response in rats under anesthesia was clarified to be mediated by activation of TRPA1 channels, which are expressed in TRPV1-expressing sensory nerves and gastric epithelial cells. This responsewas suggested to be caused by CGRP and adrenomedullin.

J Pharmacol Sci.

ELSEVIA

151

4

https://doi.org/10.1016/j.jphs.2023.02.002