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Basic information
he total synthesis of (+)-macrosphelide A (18.5% overall yield in 11 steps), (+)-macrosphelide C (25% overall yield in 9 steps), (+)-macrosphelide E (23.9% overall yield in 11 steps), (+)-macrosphelide F (20% overall yield in 9 steps), and (+)-macrosphelide G (22% overall yield in 9 steps) was achieved from a chemoenzymic reaction product (4R,5S)-4-benzyloxy-5-hydroxy-2(E)-hexenoate. |