Alkoxylation at meta position to hydroxyl group of L-tyrosine: preparation of alkyl (S)-2,4-dialkoxyphenylalaninates
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Summary
Treatment of dienone lactone I, derived from L-tyrosine, with methanol in the presence of boron trifluoride etherate gave N-protected 2,4-dimethoxyphenylalanine II (R = Me) in 76% yield. Similarly, homologs I (R = Et, CHMe2) were also produced from I. (1996), 42(1), 445-51