Academic Thesis
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Basic information
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| Name | Nakamura Hiroshi |
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Total syntheses of macrosphelides (+)-A, (-)-A and (+)-E
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Joint Author
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Total syntheses of (+)-macrosphelide A (I, R = α-Me), (18.5% overall yield in 11 steps) and (+)-macrosphelide E (I, R = β-Me), (23.9% overall yield in 11 steps) have been achieved via the chemoenzymic reaction product (4R,5S)-4-benzyloxy-5-hydroxy-2(E)-hexenoate (II). The enantiomer (-)-A (14.2% overall yield in 11 steps) of (+)-A was also synthesized from the chemoenzymic reaction product (4S,5R)-4-benzyloxy-5-hydroxy-2(E)-hexenoate
(2000), 11(13), 2753-2764
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Tetrahedron: Asymmetry
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2000/06
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