Effects of phenobarbital and dosing time on the plasma concentration and pharmacological activity of tadalafil in mice.

Hiroshi Kawai, Naoki Takeda, Naoko Kojima, Reiko Iwadate, Naomi Kudo, Atsushi Mitsumoto.

The coadministration of phenobarbital and tadalafil may suppress the plasma levels and pharmacological activities of tadalafil. Dosing time should be carefully considered to maximize the efficacy of tadalafil.

BPB Reports

8

3

https://doi.org/10.1248/bpbreports.8.3_86