[Summary] We suggest that contractile response to TRPA1 activation with allyl-isothiocyanate were mediated by TRPA1-expressing neurons, which are localized in the mouse distal colon. In addition, it is suggested that the endogenous PGs play a role in the contraction in response to allyl-isothiocyanate by interacting with TRPA1-expressing neurons. TRPA1 channels may be one of important chemosensors that sense luminal environment, and then its activity is implicated in colonic motility.
[YouTube] DDW meeting highlight: https://www.youtube.com/watch?v=y9E0Yb3aVsk
〇Kimihito Tashima, Hirobumi Shimada, Yukiko Noma, Teppei Uraba, Noriyuki Oshi, Takao Namiki, Syunji Horie (Poster presentation)
