Effect of allyl isothiocyanate, a dietary activator of TRPA1 channel, on gastric mucosal blood flow and ulcerogenesis in rats　

The 14th International Conference on Ulcer Research (Tokyo, Japan)

[Summary] We found that AITC exerts a protective effect on gastric mucosa in vivo due to an increase of GMBF.  AITC stimulates TRPA1 channels directly, whereas AITC in the high concentration (30 ~ 300 mM) also stimulates capsaicin sensitive sensory neurons via H+ back-diffusion following epithelial barrier disruption.
Kimihito Tashima, Kenjiro Matsumoto, Syunji Horie (Oral Presentation)