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| 基本情報 |
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| 氏名 |
田嶋 公人 |
| 氏名（カナ） |
タシマ キミヒト |
| 氏名（英語） |
Tashima Kimihito |
| 所属 |
薬学部 医療薬学科 |
| 職名 |
教授 |
| researchmap研究者コード |
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| researchmap機関 |
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Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.
Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
In this study, we developed dual-acting μ- and δ-opioid agonists MGM-15 and MGM-16 from 7-hydroxymitragynine for the treatment of acute and chronic pain. These findings suggest that MGM-16 could become a class of a compound with potential therapeutic utility for treating neuropathic pain.
J Pharmacol Exp Ther. 348(3):383-392,2014 doi: 10.1124/jpet.113.208108.
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