New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton

Takayama, H., Misawa, K., Okada, N., Ishikawa, H., Kitajima, M., Hatori, Y., Murayama, T., Wongseripipatana, S., Tashima, K., Matsumoto, K., and Horie, S.

This procedure, which involves masking of the reactivity of the indole nucleus at the beta-position, was utilized for the modification of the benzene ring of the indoline derivative and was applied to the preparation of potent opioid receptor agonists with the Corynanthe skeleton.

Org Lett

8

25

10.1021/ol062173k

17134252