The total synthesis of (+)-macrosphelide C (25% overall yield in nine steps), (+)-macrosphelide F (20% overall yield in nine steps) and (+)-macrosphelide G (22% overall yield in nine steps) was achieved from the chemoenzymic reaction product (4R,5S)-4-benzyloxy-5-hydroxy-(2E)-hexenoate.
(2002), 13(7), 705-713