Cancer prevention offers the most cost-effective long-term health strategy. The methanol extract of the leaves of guava (Psidium guajava) exhibits marked antitumor activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the methanol extract, five triterpene acids, uvaol, ursolic acid, corosolic acid, asiatic acid, and oleanolic acid, were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 micro g/ear) in mice, and showed marked anti-inflammatory effects, with a 50% inhibitory dose of 117–657 nmol/ear. The leaves of guava may therefore be effective for cancer prevention.
vol.5 PP.216-221
DOI: 10.6000/1927-5951.2015.05.04.1
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