Academic Thesis
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Basic information
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| Name | Akimoto Masayuki |
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Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes.
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Joint Author
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Matsumoto K, Hasegawa T, Kamei T, Koyanagi J, Takahashi T, Akimoto M, Sugibayashi K
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プロドラッグNabumetoneの還元代謝における代謝酵素を検討し、18β-HSDやAKR1Cの関与を確認した。本剤は活性代謝物6-MNAの生成に関係する酸化的代謝よりも還元代謝がin vitroでは進行しやすいことが明らかになった。
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Eur. J. Drug Metab. Pharmacokinet.
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40巻
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127
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135
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2015/08
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Exist
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English
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Research papers (academic journals)
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International
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Main Achievement