Conference

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Name Michiyoshi Nukaga
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Title

Structure-function studies of PenA β-lactamase: insights into single amino acid substitutions that mediate ceftazidime (TAZ) resistance in Burkholderia pseudomallei (Bp)  K. M. Papp-Wallace, M. Nukaga, D.A. Rholl, H. P. Schweizer, M. Taracila and R. A. Bonomo

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Journal

51th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Sept 17-20, Chicago, IL, USA

Publication Date

2011/09/17

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International Collaboration

 

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Summary

69位システインを様々なアミノ酸に置換し、その多くがタゾバクタム耐性化に寄与することを明らかにした。
X線結晶解析およびコンピュータグラフィックス

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