Allyl isothiocyanate, a pungent ingredient of wasabi, induces gastric low-grade inflammation in rats to lead to the impaired gastric motility; involvement of prostaglandin, capsaicin-sensitive sensory neurons, and nitric oxide　

Digestive Disease Week 2017 (Chicago, USA)

[Summary] We suggest that AITC induced gastric low-grade inflammation with no mucosal damage is independent on TRPA1 channels in rat stomachs, but is dependent on capsaicin-sensitive sensory neurons and endogenous prostaglandin.  In contrast, endogenous nitric oxide facilitates to suppress gastric low-grade inflammation in response to AITC.  These factors are thought to lead to low grade inflammation in gastric mucosa, resulting in the impaired motility in rodents.
〇Kimihito Tashima, Shizuki Yamaura, Kazuki Hashimoto, Yasuhiro Mori, Tomoharu Shinoki, Yuki Ishihara, Syunji Horie