Activation of TRPA1 by allyl isothiocyanate increases gastric mucosal blood flow through TRPV1-expressing and non-expressing sensory nerves in rats　

7th International Symposium on Cell/Tissue Injury and Cytoprotection/organoprotection -Focus on GI tract-　 (Sheraton Princess Kaiulani Hotel, Honolulu, Hawaii)　 *A Symposium supported by IUPHAR-GI section

   We examined the effect a TRPA1 activator allyl isothiocyanate (AITC) of gastric mucosal blood flow (GMBF) in the ex-vivo stomach of normal and sensory deafferented rats.  These results suggested that AITC increases GMBF through activation of TRPA1, but not TRPV1.  It is assumed that the increased GMBF in response to AITC is mediated by TRPA1 located on both TRPV1-expressing and TRPV1-non-expressing sensory nerves.
K. Tashima, K. Matsumoto, S. Horie (Oral Presentation)