Academic Thesis
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Basic information
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| Name | Tashima Kimihito |
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Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.
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Joint Author
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Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S.
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In this study, we developed dual-acting μ- and δ-opioid agonists MGM-15 and MGM-16 from 7-hydroxymitragynine for the treatment of acute and chronic pain. These findings suggest that MGM-16 could become a class of a compound with potential therapeutic utility for treating neuropathic pain.
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J Pharmacol Exp Ther. 348(3):383-392,2014 doi: 10.1124/jpet.113.208108.
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348
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3
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383
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392
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2014/03
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Exist
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Not exist
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English
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Research papers (academic journals)
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International
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Not International Collabolation
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10.1124/jpet.113.208108.
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PMC6067406
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