Immunogenecity of a Monovalent Pandemic Influenza A H1N1 Virus Vaccine with or without Prior Seasonal Influenza Vaccine.　

The immunogenecity of panedmic influenza A H1N1 virus(A/H1pdm) vaccine might be modified by prior seasonal trivalent influenza vaccine(sTIV) administration. We conducted a retrospective analysis of immunogenecity of 243 health care workers by HI. There was no significant difference in the ratios of antibody titres of ≧40 and fold increases in geometric mean titer. sTIV injected 7 to 10 days prior to A/H1pdm vaccine administration did not interfere with the immunogenecity of the latter.
vol.19 No.10 pp.1690-2

Clinical and Vaccine Immunology