論文[R]

基本情報

氏名 新垣 知輝
氏名(カナ) シンガキ トモテル
氏名(英語) Shingaki Tomoteru
所属 薬学部 医療薬学科
職名 准教授
researchmap研究者コード
researchmap機関

題名

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst 

単著・共著の別

共著

著者

 

担当区分

 

概要

Regioselective C-H oxidation of aliphatic molecules with synthetic catalysts is challenging. Here, we incorporated substraterecognition sites into a ruthenium porphyrin-heteroaromatic N-oxide catalyst system in order to characterize the regioselectivity for oxidation of alkanes. Specifically, we synthesized ruthenium porphyrin bearing two 6-acylaminopyridyl-2-amide moieties at anti sites and a series of substrates consisting of a polymethylene chain terminated by two quinazoline-2,4-dione moieties, each of which should form three hydrogen bonds with the catalyst. Oxidation proceeded at the central position of the polymethylene chain and selectively afforded the corresponding ketone (7-oxo) as the major product. The reaction rate was greater than that of a catalyst without recognition sites. The enhanced rate and high regioselectivity are considered to be a result of the proximity between the active intermediate and the reaction site owing to molecular recognition.
pp.8378-8381

発表雑誌等の名称

Chemical Communications

出版者

 

 

 

開始ページ

 

終了ページ

 

発行又は発表の年月

2019/06

査読の有無

 

招待の有無

 

記述言語

 

掲載種別

 

国際・国内誌

 

国際共著

 

ISSN

 

eISSN

 

DOI

 

Cinii Articles ID

 

Cinii Books ID

 

Pubmed ID

 

PubMed Central 記事ID

 

URL

形式

 

無償ダウンロード

 

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID

 

担当授業科目1

 

担当授業科目2

 

担当授業科目3

 

主要業績フラグ