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Basic information
A Dual Effect of 1-Methyl-4-phenylpyridinium (MPP+)-analogs on the Respiratory Chain of Bovine Heart Mitochondria. We synthesized various 1-methyl-4-phenylpyridinium (MPP+) derivatives and examined their structural relationships in respiratory chain inhibitory activity using isolated mitochondria. From this study, it was clarified that MPP+ analogues have both electron transfer inhibitory effect and active oxygen production enhancing effect. |