A Dual Effect of 1-Methyl-4-phenylpyridinium (MPP+)-analogs on the Respiratory Chain of Bovine Heart Mitochondria.
単著・共著の別
共著
著者
E. Hasegawa, D. Kang, K. Sakamoto, A. Mitsumoto, T. Nagano, S. Minakami, and K. Takeshige
担当区分
概要
We synthesized various 1-methyl-4-phenylpyridinium (MPP+) derivatives and examined their structural relationships in respiratory chain inhibitory activity using isolated mitochondria. From this study, it was clarified that MPP+ analogues have both electron transfer inhibitory effect and active oxygen production enhancing effect.