FICA derivatives having mono- and di-substituted benzene ring moiety (1: R = 4-Me [3], 4-Br, 5-Br, 6-Br, 4,6-di-Cl, 5,7-di-Cl) were synthesized as their methyl esters from commercially available 1-indanone derivatives. Each methyl esters was converted to a mixture of diastereomeric esters of secondary alcohols by ester exchange reaction and estimated their capability as CDA using 19F- and 1H-NMR spectroscopy. The results of our experiments showed that the position of substituents affected the F values, whereas their electron-donating or withdrawing feature did not. Especially, the F values of 4-substituted FICA esters were larger than those of the corresponding FICA esters.
