Nitric Oxide Inactivates Glyoxalase I in Cooperation with Glutathione.
単著・共著の別
共著
著者
A. Mitsumoto, K-R. Kim, G. Oshima, M. Kunimoto, K. Okawa, A. Iwamatsu, and Y. Nakagawa
担当区分
概要
The applicant has found that the activity of the detoxifying enzyme glyoxalase I decreases with conformational changes under nitric oxide-specific oxidative stress. In this study, we found and demonstrated that intracellular glutathione is essential for the activity-lowering action of glyoxalase I by nitric oxide.