Effects of phenobarbital and dosing time on the plasma concentration and
pharmacological activity of tadalafil in mice

Hiroshi Kawai, Naoki Takeda, Naoko Kojima, Reiko Iwadate, Naomi Kudo, and Atsushi Mitsumoto

The coadministration of phenobarbital and tadalafil may suppress the plasma levels and
pharmacological activities of tadalafil. Additionally, dosing time should be carefully considered to maximize the efficacy of tadalafil.

BPB Reports

Pharmaceutical Society of Japan

in press