Clofibric acid increases molecular species of phosphatidylethanolamine containing arachidonic acid for biogenesis of peroxisomal membranes in peroxisome proliferation in the liver.

Hiroaki Miura, Hiroki Mizoguchi, Mino Amano-Iwashita, Rie Maeda-Kogure, Akio negishi, Ayako Sakai, Tomoaki Toyama, Hiroshi Kawai, Atsushi Mitsumoto, Naomi Kudo

We investigated metabolic alterations induced by clofibric acid (CA), a peroxisome proliferator, in the synthesis of phospholipids, and their relationship with the biogenesis. CA markedly increased the formation of particular PE molecular species is related to increases in the mass of peroxisomal membranes in peroxisome proliferation in the liver.

BBA, Mol.Cell Biol.Lipids

1866

Doi.org/10.1016/j.bbalip.2021.158963