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Basic information
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Horie Shunji |
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Researcher Basic Information
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Researcher Activity Information
- Daikenchuto, a traditional Kampo medicine, facilitates mucosal hyperemic responses through activation of TRPA1- and TRPV1-expressing sensory nerves in rat stomach/Yoshikubo, M.
Tashima, K.
Raimura, M.
Watanabe, Y.
Noma, N.
Horie, S./Joint Author/Planta Medica International Open 2022; 9(01): e72-e79
/2022/03
- Juvenile social defeat stress exposure results in later onset of irritable bowel syndrome-like symptoms in mice/Matsumoto K
Takata K
Yamada D
Usuda H
Wada K
Tada M
Mishima Y
Ishihara S
Horie S
Kato S/Joint Author/Sci Rep. 2021 Aug 11;11(1):16276/2021/08
- The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia./Hashimoto K
Tashima K
Imai T
Matsumoto K
Horie S/Joint Author/J Pharmacol Sci. 2021 Jan;145(1):122-129/2021/01
/Joint Author/2021/04
/Joint Author/2019/05
- Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of post-operative ileus./Matsumoto K
Kawanaka H
Hori M
Kusamori K
Utsumi D
Tsukahara T
Amagase K
Horie S
Yamamoto A
Ozaki H
Mori Y
Kato S/Joint Author/Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G104-G116/2018/01
- L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°,+ transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments./Yamane S
Nomura R
Yanagihara M
Nakamura H
Fujino H
Horie S
Murayama T
/Joint Author/Eur J Pharmacol., 764, 471-479/2017/01
- Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity./Matsumoto K
Takagi K
Kato A
Ishibashi T
Mori Y
Mitsumoto A
Kato S
Horie S/Joint Author/Experimental Neurology, 285 (Pt A):41-50/2016/11
- Serotonin/5-hydroxytryptamine-3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis./Utsumi D
Matsumoto K
Amagase K
Horie S
Kato S/Joint Author/Br. J. Pharmacol., 173(11), 1835-1849/2016/03
- Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral µ-opioid receptors in mice./Matsumoto K
Umemoto H
Mori T
Akatsu R
Saito S
Tashima K
Shibasaki M
Kato S
Suzuki T
Horie S/Joint Author/Eur J Pharmacol. 771, 220-228/2016/01
- 胃粘膜上皮バリア機能調節におけるワサビ受容体TRPA1の役割 単著 Ulcer Research 42, 32-34 (2015) 2016/01
- Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus/Joint Author/Br J Pharmacol, 172(4):1136-1147/2015/01
- L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments/Joint Author/2015/01
- 大建中湯のラット胃粘膜血流の増大作用：温度感受性チャネルTRPV1およびTRPA1チャネルの役割 共著 Ulcer Research 42巻 2015/01
- 温度感受性TRPチャネルアンタゴニスト活性を有するVoacangine型アルカロイドの探索・合成と構造活性相関研究 共著 Med Chem News 25巻3号 2015/01
- キーワード解説 TRPチャネルと内臓痛 共著 日本薬理学雑誌 146巻 2015/01
- Voacanga africana由来アルカロイドvoacangineの温度感受性TRPチャネルに対する活性・阻害作用 共著 食品加工技術 35巻2号 2015/01
- Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice./J Pharmacol Exp Ther, 348:383-392 (2014)/2014/03
- TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice./Hosoya T, Matsumoto K, Tashima K, Nakamura H, Fujino H, Murayama T, Horie S./Neurogastroenterol Motil, 26:1112-1121 (2014)/2014/01
- Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon./Sakai H, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M./Pharmacol. Res., 87: 71-79 (2014)/2014/05
- Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus./Matsumoto K, Hosoya T, Ishikawa E, Tashima K, Amagase K, Kato S, Murayama T, Horie S./Joint Author/Histochem Cell Biol, 142(6): 635-644/2014/07
- Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives./Terada Y, Kitajima M, Taguchi F, Takayama H, Horie S, Watanabe T./2014/08
- Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation./Joint Author/Neurogastroenterol Motil., 26(10): 1396-1407(2014)/2014/10
- Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree./Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T./J. Nat. Prod., 77(2): 285-97 (2014) /2014/02
- 5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines./Sakai H, Sagara A, Matsumoto K, Hasegawa S, Sato K, Nishizaki M, Shoji T, Horie S, Nakagawa T, Tokuyama S, Narita M./PLoS ONE 8(1): e54788 (2013)/2013/01
- Bee venom phospholipase A2-induced phasic contractions in mouse rectum: Independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis./Nomura R, Yanagihara M, Sato H, Matsumoto K, Tashima K, Horie S, Chen S, Fujino H, Ueno K, Murayama T./Eur. J. Pharmacol., 718(1-3):314-322 (2013)/2013/01
- Increased expression of 5-HT3 and NK1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum./Matsumoto K, Nakajima T, Sakai H, Kato S, Sagara A, Arakawa K, Tashima K, Narita M, Horie S./Joint Author/Dig. Dis. Sci., 58(12), 3440-3451 (2013)/2013/01
- Mechanisms that underlie μ-opioid receptor agonist-induced constipation; differential involvement of μ-opioid receptor sites and responsible regions./Mori T, Shibasaki Y, Matsumoto K, Shibasaki M, Hasegawa M, Masukawa D, Yoshizawa K, Horie S, Suzuki T./J. Pharmacol. Exp. Ther., 347(1):91-99 (2013)/2013/01
- Neuronal nitric oxide synthase-derived nitric oxide Is involved in gastric mucosal hyperemic response to capsaicin in rats./Raimura M, Tashima K, Matsumoto K, Tobe S, Chino A, Namiki T, Terasawa K, Horie S./Pharmacology., 92(1-2):60-70 (2013)/2013/01
- Serotonin 5-HT(3) receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in mice intestinal crypt cells./Yasuda M, Kato S, Yamanaka N, Iimori M, Matsumoto K, Utsumi D, Kitahara Y, Amagase K, Horie S, Takeuchi K./Br. J. Pharmacol., 168(6):1388-1400 (2013)/2013/01
- Dietary agonists of TRPV1 inhibit gastric acid secretion in mice./Okumi H, Tashima K, Matsumoto K, Namiki T, Terasawa K, Horie S./Planta Med. 2012 Nov;78(17):1801-6 (2012)/2012/01
- Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice./Matsumoto, K., Lo, Wah, M., Hosoya, T., Tashima, K., Takayama, H., Murayama, T., Horie, S./Joint Author/Lab Invest. 2012 May;92(5):769-82 (2012)/2012/01
- Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: Pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors./Kato S, Matsuda N, Matsumoto K, Wada M, Onimaru N, Yasuda M, Amagase K, Horie S, Takeuchi K./Joint Author/Pharmacol Res., 66(3):226-234 (2012) Sep/2012/09
- Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons 共著 Neuroscience 172巻 2011/01
- Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum 共著 Journal of Natural Medicine 65巻1号 2011/01
- Neurogenic contraction of mouse rectum via the cyclooxygenase pathway: Changes of PGE2-induced contraction with dextran sulfate sodium-induced colitis 共著 Pharmacological Research 61巻1号 2010/01
- Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats 共著 Neuroscience 164巻3号 2009/12
- Nicotine-induced neurogenic relaxation in the mouse colon; changes with dextran sodium sulfate-induced colitis/Joint Author/2009/01
- Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon 共著 Am. J. Physiol. Gastrointest. Liver Physiol. 297巻2号 2009/08
- Daikenchuto, a traditional Kampo medicine, facilitates mucosal hyperemic responses through activation of TRPA1- and TRPV1-expressing sensory nerves in rat stomach/Yoshikubo, M./Joint Author/Planta Medica International Open 2022; 9(01): e123/2022/06
- Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized guinea pigs./Watanabe, N., Horie, S., Spina, D., Michael, G.J., Page, C.P., Priestley, J.V./International Archives of Allergy and Immunology, 146(1), 28-32 (2008)/2008/01
- The Chemical Constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid./Zhang, G., Shimokawa, S., Mochizuki, M., Kumamoto, T., Nakanishi, W., Watanabe, T., Ishikawa, T., Matsumoto, K., Tashima, K., Horie, S., Higuchi, Y., Dominguez, O.P./ J. Natural Products, 71, 1167-1172 (2008)/2008/01
- Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice./Matsumoto, K., Kimura, H., Tashima, K., Uchida, M., Horie, S./Joint Author/Biol. Pharm. Bull., 31(10), 1917-1922 (2008)/2008/01
- MGM-9, a derivative of the indole alkaloid mitragynine: a novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice./Matsumoto, K., Takayama, H., Narita, M., Nakamura, A., Suzuki, M., Suzuki, T., Murayama, T., Wongseripipatana, S., Misawa, K., Kitajima, M., Tashima, K., Horie, S./Joint Author/Neuropharmacology, 55(2), 154-165 (2008)/2008/01
- Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation./Sasaki, M., Nakamura, H., Tsuchiya, S., Horie, S., Kashiwayanagi, M., Saito, T., Murayama, T./Joint Author/Biol. Pharm. Bull., 30(4), 682-686 (2007)/2007/01
- Effect of capsaicin via TRPV1 in isolated mouse lower gastrointestinal tract and the influence of neonatal stress./Horie, S., Matsumoto, K., Tashima, K./Autonomic Neuroscience, 135(1-2), 96-97 (2007)/2007/01
- Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine./Penuelas, A, Tashima, K., Tsuchiya, S., Matsumoto, K., Nakamura, T., Horie, S., Yano, S./Eur. J. Pharmacol., 576(1-3), 143-50 (2007)/2007/01
- Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum./Matsumoto, K., Takayama, H., Ishikawa, H., Aimi, N., Ponglux, D., Watanabe, K., Horie, S./Life Sciences, 78(19), 2265-2271 (2006)/2006/01
- A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity./Kitajima, M., Misawa, K., Kogure, N., Said, I.M., Horie, S., Hatori, Y., Murayama, T., Takayama, H./Joint Author/J. Natural Medicines, 60(1), 28-35 (2006)/2006/01
- Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa./Matsumoto, K., Hatori, Y., Murayama, T., Tashima, K., Wongseripipatana, S., Misawa, K., Kitajima, M., Takayama, H., Horie, S./Joint Author/European Journal of Pharmacology, 549(1-3):63-70 (2006)/2006/01
- Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system./Watanabe, N., Horie, S., Michael, G.J., Keir, S., Spina, D., Page, C.P., Priestley, J.V./Joint Author/Neuroscience, 141(3), 1533-1543 (2006)/2006/01
- Stimulatory effects of endogenous and exogenous nitric oxide on gastric acid secretion in anesthetized rats./Hasebe, K., Horie, S., Noji, T., Watanabe, K., Yano, S./Joint Author/Nitric Oxide, 13(4), 264-271 (2005)/2005/01
- Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach./Ochi, Y, Horie, S., Maruyama, T., Watanabe, K., Yano, S./Life Sciences, 77(16), 2040-2050 (2005)/2005/01
- Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens./Matsumoto, K., Yamamoto, L.T., Watanabe, K., Yano, S., Shan, J., Pang, P.K.T., Ponglux, D., Takayama, H., Horie, S./Joint Author/Life Sci., 78(2), 187-194 (2005)/2005/01
- Colocalization of TRPV1-expressing nerve fibers with calcitonin gene-related peptide and substance P in fundus of rat stomach./Horie, S., Michael, G.J., Priestley, J.V./Inflammopharmacology, 13(1), 127-137 (2005)/2005/01
- Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain./Minowa, S., Ishihara, S., Tsuchiya, S., Horie, S., Murayama T./Brain Res., 1039 (1-2), 75-83 (2005)/2005/01
- Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons./Matsumoto, K., Hosoya, T., Tashima, K., Namiki, T., Murayama, T., Horie, S./Neuroscience, 172, 518-534 (2011)/2012/01
- Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment./Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T./Joint Author/Naunyn-Schmiedeberg Arch. Pharmacol., 385(1):81-94 (2012)/2012/01
- Dysfunction of neurogenic VIP-mediated relaxation in mouse distal colon with dextran sulfate sodium-induced colitis./Kato E, Yamane, S, Nomura R, Matsumoto K, Tashima K, Horie S, Saito T, Fujino H, Murayama T./Joint Author/Pharmacological Research, 65(2):204-212 (2012) Feb/2012/02
- Subdiaphragmatic vagotomy induces a functional change in visceral Aδ primary afferent fibers in rats./Furuta S, Matsumoto K, Horie S, Suzuki T, Narita M./Joint Author/Synapse, 66(4):369-71 (2012)/2012/04
- 漢方薬特有の臨床適用を薬理学的に翻訳する 単著 漢方の臨床 62巻6号 2015/01
- 薬学基礎研究を通して研究マインドを持った薬剤師を育てる 単著 日本病院薬剤師会雑誌 2010/11
- New Procedure to Mask the 2,3- Bond of the Indole Nucleus and Its Application to the Preparation of Potent Opioid Receptor Agonists with a Corynanthe Skeleton./Takayama, H., Misawa, K., Okada, N., Ishikawa, H., Kitajima, M., Hatori, Y., Murayama, T., Wongseripipatana, S., Tashima, K., Matsumoto, K., Horie, S./Organic Letters, 8(25), 5705-5708 (2006)/2006/01
- Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment./Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T./Naunyn-Schmiedeberg Arch. Pharmacol., 385(1):81-94 (2012)/2012/01
- アドレノメデュリン 堀江俊治 単著 臨床栄養（臨時増刊号）, 128(6), 782～786 (2016) 2016/06
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- マウス下部消化管におけるTRPV1発現神経の分布と神経ペプチド, セロトニン, NO合成酵素の局在に関する免疫組織学的検討 ［シンポジウム講演］ 第6回日本消化管学会 （福岡） 2010/02/19
- A Novel Aspect of Pharmacology on Aconite: Nitric oxide (NO)- and endothelium-derived hyperpolarizing factor (EDHF)-mediated, endothelium-dependent vasorelaxation by aconite alkaloids ［国際学会シンポジウム講演］ The 15th International Congress of Oriental Medicine （千葉） 2010/02/26
- マウス摘出下部消化管標本における平滑筋張力に対するワサビ辛味成分アリルイソチオシアネートの冷刺激受容体TRPA1を介する収縮作用：内因性一酸化窒素(NO)／神経型NO合成酵素の関与 第83回日本薬理学会年会 （大阪） 2010/03/16
- マウス下部消化管におけるTRPM8チャネルの分布とTRPM8作動薬の平滑筋弛緩作用 第83回日本薬理学会年会 （大阪） 2010/03/16
- Relaxatory responses of mouse lower gastrointestinal tract mediated to transient receptor potential melastatin type-8 (TRPM8) channel activation Digestive Disease Week 2010 (New Orleans, USA) 2010/05/01
- Immunohistochemical characterisation of TRPV1-expressing nerve fibers and serotonin signalling in mouse rectum Digestive Disease Week 2010 (New Orleans, USA) 2010/05/01
- Effect of Allyl Isothiocyanate, A Pungent Ingredient of Wasabi and Mustard Oil, on Gastric Mucosal Blood Flow and Ulcerogenesis in Rats: Comparison with Capsaicin Digestive Disease Week 2010 (New Orleans, USA) 2010/05/01
- Distribution of transient receptor potential vanilloid (TRPV) 1 channels-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons and interstitial cells of Cajal (ICC) Digestive Disease Week 2010 (New Orleans, USA) 2010/05/01
- 麻酔下ラットにおけるワサビ辛味成分アリルイソチオシアネートによる胃粘膜傷害性と粘膜血流増大反応 第27回和漢医薬学会学術大会 （京都） 2010/08/28
- 麻酔下ラットにおけるワサビ辛味成分アリルイソチオシアネートの胃粘膜傷害性 -タイトジャンクションバリアと粘膜血流による胃粘膜防御機構- ［シンポジウム講演］ 生体機能と創薬シンポジウム2010 （京都) 2010/09/10
- 麻酔下ラットにおけるワサビ辛味成分アリルイソチオシアネートの胃粘膜傷害性とそれに対する粘膜防御反応 第25回日本香辛料研究会 （静岡） 2010/11/13
- トウガラシ辛味成分カプサイシンの麻酔下ラット胃粘膜血流増大作用における神経型NO合成酵素の関与 第25回日本香辛料研究会 （静岡） 2010/11/13
- 動物実験代替法を取入れた薬学部の学内実習 第23回日本動物実験代替法学会 （東京） 2010/12/03
- マウスDDS誘起大腸炎モデルにおけるセロトニンシグナリングとバニロイド受容体TRPV1発現神経の変化 ［ワークショップ］ 第7回日本消化管学会総会学術集会 （京都） 2011/02/18
- 炎症性腸疾患モデルマウスにおけるセロトニン関連因子とバニロイド受容体TRPV1発現神経の変化 ［シンポジウム講演］ 第84回日本薬理学会年会 （横浜） 2011/03/24
- 麻酔下ラットにおけるワサビ辛味成分アリルイソチオシアネートの胃粘膜傷害性と胃粘膜血流増大反応 日本薬学会第131年会 （静岡） 2011/03/29
- トウガラシの辛味は胃腸でも味わう：胃におけるバニロイド受容体TRPV1の分布と機能 ［シンポジウム］ 日本薬学会第131年会 （静岡） 2011/03/29
- ラット胃食道逆流症慢性モデルの下部食道粘膜と括約筋における温度感受性TRPV1およびTRPM8チャネル発現神経の増大 小出恵未、立花千紗土、篠木智春、松本建次郎、田嶋公人、堀江俊治 第21回日本神経消化器病学会 （小田原：2020年1月16日～17日）口頭発表 2020/01/17
- Allyl isothiocyanate, an activator of TRPA1 channel, increases gastric mucosal blood flow through TRPV1-expressing and non-expressing sensory nerves in rats: involvement of calcitonin gene-related peptide/Kimihito Tashima, Noriyuki Ohashi, Masatoshi Yoshikubo, Marina Oshige, Takao Namiki, Syunji Horie/Digestive Disease Week 2020 (May 2-5, 2020, Chicago, USA)/2020/05/02
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