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基本情報
| 氏名 |
堀江 俊治 |
| 氏名（カナ） |
ホリエ シュンジ |
| 氏名（英語） |
Horie Shunji |
| 所属 |
薬学部 医療薬学科 |
| 職名 |
教授 |
| researchmap研究者コード |
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| researchmap機関 |
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- Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats./Ohashi N, Tashima K, Namiki T, Horie S./Joint Author/ J Pharmacol Sci./2023/04
- Immunohistochemical characterization of transient receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity./Matsumoto K, Sugimoto F, Mizuno T, Hayashi T, Okamura R, Nishioka T, Yasuda H, Horie S, Kido MA, Kato S./Cell Tissue Res./2023/09
- Daikenchuto, a traditional Kampo medicine, facilitates mucosal hyperemic responses through activation of TRPA1- and TRPV1-expressing sensory nerves in rat stomach Yoshikubo, M.
Tashima, K.
Raimura, M.
Watanabe, Y.
Noma, N.
Horie, S. 共著 Planta Medica International Open 2022; 9(01): e72-e79 2022/03
- Juvenile social defeat stress exposure results in later onset of irritable bowel syndrome-like symptoms in mice Matsumoto K
Takata K
Yamada D
Usuda H
Wada K
Tada M
Mishima Y
Ishihara S
Horie S
Kato S 共著 Sci Rep. 2021 Aug 11;11(1):16276 2021/08
- The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia. Hashimoto K
Tashima K
Imai T
Matsumoto K
Horie S 共著 J Pharmacol Sci. 2021 Jan;145(1):122-129 2021/01
- 過敏性腸症候群モデルの結腸における低温感受性TRPM8神経の増加 堀江俊治
村松寛英
川島孝浩
田嶋公人 共著 細胞，53(4), 260-263 (2021) 2021/04
- 逆流性食道炎における胸やけ症状へのTRPV1 の関与． 小出恵未
松本健次郎
田嶋公人
堀江俊治 共著 Ulcer Reaserch, 46, 2019, 46:54-57 2019/05
- Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of post-operative ileus. Matsumoto K
Kawanaka H
Hori M
Kusamori K
Utsumi D
Tsukahara T
Amagase K
Horie S
Yamamoto A
Ozaki H
Mori Y
Kato S 共著 Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G104-G116 2018/01
- L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°,+ transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments. Yamane S
Nomura R
Yanagihara M
Nakamura H
Fujino H
Horie S
Murayama T
共著 Eur J Pharmacol., 764, 471-479 2017/01
- Role of transient receptor potential melastatin 2 (TRPM2) channels in visceral nociception and hypersensitivity. Matsumoto K
Takagi K
Kato A
Ishibashi T
Mori Y
Mitsumoto A
Kato S
Horie S 共著 Experimental Neurology, 285 (Pt A):41-50 2016/11
- Serotonin/5-hydroxytryptamine-3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis. Utsumi D
Matsumoto K
Amagase K
Horie S
Kato S 共著 Br. J. Pharmacol., 173(11), 1835-1849 2016/03
- Differences in the morphine-induced inhibition of small and large intestinal transit: Involvement of central and peripheral µ-opioid receptors in mice. Matsumoto K
Umemoto H
Mori T
Akatsu R
Saito S
Tashima K
Shibasaki M
Kato S
Suzuki T
Horie S 共著 Eur J Pharmacol. 771, 220-228 (2016) 2016 Jan 15 2016/01
- 胃粘膜上皮バリア機能調節におけるワサビ受容体TRPA1の役割 単著 Ulcer Research 42, 32-34 (2015) 2016/01
- Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in postoperative ileus 共著 Br J Pharmacol, 172(4):1136-1147 2015/01
- L-cysteine/d,L-homocysteine-regulated ileum motility via system L and B°(,+) transporter: Modification by inhibitors of hydrogen sulfide synthesis and dietary treatments 共著 Eur J Pharmacol 726巻 pp. 471-479 2015/01
- 大建中湯のラット胃粘膜血流の増大作用：温度感受性チャネルTRPV1およびTRPA1チャネルの役割 共著 Ulcer Research 42巻 2015/01
- 温度感受性TRPチャネルアンタゴニスト活性を有するVoacangine型アルカロイドの探索・合成と構造活性相関研究 共著 Med Chem News 25巻3号 2015/01
- キーワード解説 TRPチャネルと内臓痛 共著 日本薬理学雑誌 146巻 2015/01
- Voacanga africana由来アルカロイドvoacangineの温度感受性TRPチャネルに対する活性・阻害作用 共著 食品加工技術 35巻2号 2015/01
- Orally Active Opioid μ/δ Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice. Matsumoto K, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S. J Pharmacol Exp Ther, 348:383-392 (2014) 2014/03
- TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. Hosoya T, Matsumoto K, Tashima K, Nakamura H, Fujino H, Murayama T, Horie S. Neurogastroenterol Motil, 26:1112-1121 (2014) 2014/01
- Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon. Sakai H, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M. Pharmacol. Res., 87: 71-79 (2014) 2014/05
- Distribution of transient receptor potential cation channel subfamily V member 1-expressing nerve fibers in mouse esophagus. Matsumoto K, Hosoya T, Ishikawa E, Tashima K, Amagase K, Kato S, Murayama T, Horie S. 共著 Histochem Cell Biol, 142(6): 635-644 2014/07
- Identification of Indole Alkaloid Structural Units Important for Stimulus-Selective TRPM8 Inhibition: SAR Study of Naturally Occurring Iboga Derivatives. Terada Y, Kitajima M, Taguchi F, Takayama H, Horie S, Watanabe T. J. Nat. Prod., 77 (8), 1831–1838 2014/08
- Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation. Ono H, Nakamura A, Matsumoto K, Horie S, Sakaguchi G, Kanemasa T. 共著 Neurogastroenterol Motil., 26(10): 1396-1407(2014) 2014/10
- Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree. Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T. J. Nat. Prod., 77(2): 285-97 (2014) 2014/02
- 5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines. Sakai H, Sagara A, Matsumoto K, Hasegawa S, Sato K, Nishizaki M, Shoji T, Horie S, Nakagawa T, Tokuyama S, Narita M. PLoS ONE 8(1): e54788. doi:10.1371/journal.pone.0054788 (2013) 2013/01
- Bee venom phospholipase A2-induced phasic contractions in mouse rectum: Independent roles of eicosanoid and gap junction proteins and their loss in experimental colitis. Nomura R, Yanagihara M, Sato H, Matsumoto K, Tashima K, Horie S, Chen S, Fujino H, Ueno K, Murayama T. Eur. J. Pharmacol., 718(1-3):314-322 (2013) 2013/01
- Increased expression of 5-HT3 and NK1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. Matsumoto K, Nakajima T, Sakai H, Kato S, Sagara A, Arakawa K, Tashima K, Narita M, Horie S. 共著 Dig. Dis. Sci., 58(12), 3440-3451 (2013) 2013/01
- Mechanisms that underlie μ-opioid receptor agonist-induced constipation; differential involvement of μ-opioid receptor sites and responsible regions. Mori T, Shibasaki Y, Matsumoto K, Shibasaki M, Hasegawa M, Masukawa D, Yoshizawa K, Horie S, Suzuki T. J. Pharmacol. Exp. Ther., 347(1):91-99 (2013) 2013/01
- Neuronal nitric oxide synthase-derived nitric oxide Is involved in gastric mucosal hyperemic response to capsaicin in rats. Raimura M, Tashima K, Matsumoto K, Tobe S, Chino A, Namiki T, Terasawa K, Horie S. Pharmacology., 92(1-2):60-70 (2013) 2013/01
- Serotonin 5-HT(3) receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in mice intestinal crypt cells. Yasuda M, Kato S, Yamanaka N, Iimori M, Matsumoto K, Utsumi D, Kitahara Y, Amagase K, Horie S, Takeuchi K. Br. J. Pharmacol., 168(6):1388-1400 (2013) 2013/01
- Dietary agonists of TRPV1 inhibit gastric acid secretion in mice. Okumi H, Tashima K, Matsumoto K, Namiki T, Terasawa K, Horie S. Planta Med. 2012 Nov;78(17):1801-6 (2012) 2012/01
- Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. Matsumoto, K., Lo, Wah, M., Hosoya, T., Tashima, K., Takayama, H., Murayama, T., Horie, S. 共著 Lab Invest. 2012 May;92(5):769-82 (2012) 2012/01
- Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: Pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Kato S, Matsuda N, Matsumoto K, Wada M, Onimaru N, Yasuda M, Amagase K, Horie S, Takeuchi K. 共著 Pharmacol Res., 66(3):226-234 (2012) 2012/09
- Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons 共著 Neuroscience 172巻 2011/01
- Inhibitory effect of Iboga-type indole alkaloids on capsaicin-induced contraction in isolated mouse rectum 共著 Journal of Natural Medicine 65巻1号 2011/01
- Neurogenic contraction of mouse rectum via the cyclooxygenase pathway: Changes of PGE2-induced contraction with dextran sulfate sodium-induced colitis 共著 Pharmacological Research 61巻1号 2010/01
- Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats 共著 Neuroscience 164巻3号 2009/12
- Nicotine-induced neurogenic relaxation in the mouse colon; changes with dextran sodium sulfate-induced colitis 共著 Journal of Pharmacological Sciences 2009/01
- Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon 共著 Am. J. Physiol. Gastrointest. Liver Physiol. 297巻2号 2009/08
- Daikenchuto, a traditional Kampo medicine, facilitates mucosal hyperemic responses through activation of TRPA1- and TRPV1-expressing sensory nerves in rat stomach 共著 Planta Medica International Open 2022; 9(01): e123 2022/06
- Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized guinea pigs. Watanabe, N., Horie, S., Spina, D., Michael, G.J., Page, C.P., Priestley, J.V. International Archives of Allergy and Immunology, 146(1), 28-32 (2008) 2008/01
- The Chemical Constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. Zhang, G., Shimokawa, S., Mochizuki, M., Kumamoto, T., Nakanishi, W., Watanabe, T., Ishikawa, T., Matsumoto, K., Tashima, K., Horie, S., Higuchi, Y., Dominguez, O.P. J. Natural Products, 71, 1167-1172 (2008) 2008/01
- Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice. Matsumoto, K., Kimura, H., Tashima, K., Uchida, M., Horie, S. 共著 Biol. Pharm. Bull., 31(10), 1917-1922 (2008) 2008/01
- MGM-9, a derivative of the indole alkaloid mitragynine: a novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice. Matsumoto, K., Takayama, H., Narita, M., Nakamura, A., Suzuki, M., Suzuki, T., Murayama, T., Wongseripipatana, S., Misawa, K., Kitajima, M., Tashima, K., Horie, S. 共著 Neuropharmacology, 55(2), 154-165 (2008) 2008/01
- Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation. Sasaki, M., Nakamura, H., Tsuchiya, S., Horie, S., Kashiwayanagi, M., Saito, T., Murayama, T. 共著 Biol. Pharm. Bull., 30(4), 682-686 (2007) 2007/01
- Effect of capsaicin via TRPV1 in isolated mouse lower gastrointestinal tract and the influence of neonatal stress. Horie, S., Matsumoto, K., Tashima, K. Autonomic Neuroscience, 135(1-2), 96-97 (2007) 2007/01
- Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. Penuelas, A, Tashima, K., Tsuchiya, S., Matsumoto, K., Nakamura, T., Horie, S., Yano, S. Eur. J. Pharmacol., 576(1-3), 143-50 (2007) 2007/01
- Partial agonistic effect of 9-hydroxycorynantheidine on mu-opioid receptor in the guinea-pig ileum. Matsumoto, K., Takayama, H., Ishikawa, H., Aimi, N., Ponglux, D., Watanabe, K., Horie, S. Life Sciences, 78(19), 2265-2271 (2006) 2006/01
- A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity. Kitajima, M., Misawa, K., Kogure, N., Said, I.M., Horie, S., Hatori, Y., Murayama, T., Takayama, H. 共著 J. Natural Medicines, 60(1), 28-35 (2006) 2006/01
- Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa. Matsumoto, K., Hatori, Y., Murayama, T., Tashima, K., Wongseripipatana, S., Misawa, K., Kitajima, M., Takayama, H., Horie, S. 共著 European Journal of Pharmacology, 549(1-3):63-70 (2006) 2006/01
- Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Watanabe, N., Horie, S., Michael, G.J., Keir, S., Spina, D., Page, C.P., Priestley, J.V. 共著 Neuroscience, 141(3), 1533-1543 (2006) 2006/01
- Stimulatory effects of endogenous and exogenous nitric oxide on gastric acid secretion in anesthetized rats. Hasebe, K., Horie, S., Noji, T., Watanabe, K., Yano, S. 共著 Nitric Oxide, 13(4), 264-271 (2005) 2005/01
- Necessity of intracellular cyclic AMP in inducing gastric acid secretion via muscarinic M3 and cholecystokinin2 receptors on parietal cells in isolated mouse stomach. Ochi, Y, Horie, S., Maruyama, T., Watanabe, K., Yano, S. Life Sciences, 77(16), 2040-2050 (2005) 2005/01
- Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens. Matsumoto, K., Yamamoto, L.T., Watanabe, K., Yano, S., Shan, J., Pang, P.K.T., Ponglux, D., Takayama, H., Horie, S. 共著 Life Sci., 78(2), 187-194 (2005) 2005/01
- Colocalization of TRPV1-expressing nerve fibers with calcitonin gene-related peptide and substance P in fundus of rat stomach. Horie, S., Michael, G.J., Priestley, J.V. Inflammopharmacology, 13(1), 127-137 (2005) 2005/01
- Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. Minowa, S., Ishihara, S., Tsuchiya, S., Horie, S., Murayama T. Brain Res., 1039 (1-2), 75-83 (2005) 2005/01
- Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons. Matsumoto, K., Hosoya, T., Tashima, K., Namiki, T., Murayama, T., Horie, S. Neuroscience, 172, 518-534 (2011) 2012/01
- Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment. Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T. 共著 Naunyn-Schmiedeberg Arch. Pharmacol., 385(1):81-94 (2012) 2012/01
- Dysfunction of neurogenic VIP-mediated relaxation in mouse distal colon with dextran sulfate sodium-induced colitis. Kato E, Yamane, S, Nomura R, Matsumoto K, Tashima K, Horie S, Saito T, Fujino H, Murayama T. 共著 Pharmacological Research, 65(2):204-212 (2012) Feb 2012/02
- Subdiaphragmatic vagotomy induces a functional change in visceral Aδ primary afferent fibers in rats. Furuta S, Matsumoto K, Horie S, Suzuki T, Narita M. 共著 Synapse, 66(4):369-71 (2012) 2012/04
- Localization of thermosensitive TRPV1 in Gastrointestinal Tracts and Its Change in Gastrointestinal Disease Model Animals. Horie, S., Tashima, K. 共著 J. Balneol. Climatol. Phys. Med., 84(1), 36 (2021) March 2021 2021/03
- 逆流性食道炎とは． 小出恵未
堀江俊治 共著 Suzuken Medical, 22(3), pp. 15 2019/06
- 逆流性食道炎のくすり 小出恵未
堀江俊治 共著 Suzuken Pharma, 22(3), pp. 7 2019/06
- 胃酸関連疾患の病態と治療 医学書院 2000/08
- 消化管スパイスセンサーとその機能：辛味は胃腸でも味わう 堀江俊治、田嶋公人、松本健次郎 薬学雑誌(YAKUGAKU ZASSHI), 138(8), 1003-1009 （2018） 2018/08
- 漢方薬特有の臨床適用を薬理学的に翻訳する 単著 漢方の臨床 62巻6号 2015/01
- 薬学基礎研究を通して研究マインドを持った薬剤師を育てる 単著 日本病院薬剤師会雑誌 2010/11
- New Procedure to Mask the 2,3- Bond of the Indole Nucleus and Its Application to the Preparation of Potent Opioid Receptor Agonists with a Corynanthe Skeleton. Takayama, H., Misawa, K., Okada, N., Ishikawa, H., Kitajima, M., Hatori, Y., Murayama, T., Wongseripipatana, S., Tashima, K., Matsumoto, K., Horie, S. Organic Letters, 8(25), 5705-5708 (2006) 2006/01
- Decrease of guanylyl cyclase β1 subunit and nitric oxide (NO)-induced relaxation in mouse rectum with colitis and its reproduction on long-term NO treatment. Hamada Y, Kato E, Nakamura H, Fujino H, Matsumoto K, Tashima K, Horie S, Murayama T. Naunyn-Schmiedeberg Arch. Pharmacol., 385(1):81-94 (2012) 2012/01
- アドレノメデュリン 堀江俊治 単著 臨床栄養（臨時増刊号）, 128(6), 782～786 (2016) 2016/06
- センノシドA誘発慢性結腸通過遅延マウスモデルにおける結腸運動に対する大建中湯の改善作用 趙春暁、田嶋公人、並木 隆雄、堀江 俊治 応用薬理シンポジウム 2021/09/04
- ポストコロナにおけるデキストラン硫酸誘起炎症後過敏性腸症候群マウスモデルにおける下部消化管痛覚過敏症状と病態生理の解析 堀江俊治、植松若那、斉藤栄樹、道宗優也、川島孝浩、田嶋公人 応用薬理シンポジウム 2021/09/04 石毛久美子
- デキストラン硫酸ナトリウム誘起炎症後過敏性腸症候群モデル動物における免疫細胞の動態と病態生理の解析―肥満細胞と温度感受性TRPV1チャネルの関与― 田嶋公人、堀江俊治 生体機能と創薬シンポジウム 2021/08/27
- ラット胃食道逆流症慢性モデルの下部食道粘膜と括約筋における温度感受性TRPV1およびTRPM8チャネル発現神経の増大 小出恵未、立花千紗土、篠木智春、松本建次郎、田嶋公人、堀江俊治 第21回日本神経消化器病学会 （小田原：2020年1月16日～17日）口頭発表 2020/01/17
- Allyl isothiocyanate, an activator of TRPA1 channel, increases gastric mucosal blood flow through TRPV1-expressing and non-expressing sensory nerves in rats: involvement of calcitonin gene-related peptide Kimihito Tashima, Noriyuki Ohashi, Masatoshi Yoshikubo, Marina Oshige, Takao Namiki, Syunji Horie Digestive Disease Week 2020 (May 2-5, 2020, Chicago, USA) 2020/05/02
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